The core of AGE Amadori is two unique B vitamins: the world’s first pharmaceutical-grade‡ Pyridox-amine, a form of vitamin B6 (not the common pyridoxine form), and Benfotiamine, an extremely well absorbed and utilized form of vitamin B1. These nutrients are Amadorins, powerful “late-phase” inhibitors of the formation of Advanced Glycation Endproducts (AGEs). In the body, AGEs form when the structure of bodily proteins is warped by exposure to blood sugar, leading to crosslinking, stiffening, and loss of function. Also includes a complete, balanced spectrum of B vitamins, including the newly-discovered redox-cofactor nutrient pyrroloquinoline quinone (PQQ), essential for the activity of the lysine-metabolizing enzyme AAS-dehydrogenase.
We all get old; it is the only justice in this world, or so the saying goes. Yet that may change as our understanding of the aging process keeps improving. There are two well-established mechanisms of slow cellular degeneration that reveal the aging process and lead to the degeneration of our tissues. One of those is the generation of free radicals. Free radicals are atoms with an unpaired electron. They react with cells extracting the missing electron. This causes cellular damage and leaves the cell permanently injured.
There is another process that leaves cells warpped and wounded: glycation reactions. These reactions hinder the function and damage the structure of proteins, and have been linked to many progressive diseases of aging. Advanced glycation end-products (AGEs) form when the structure of the proteins found in our body is damaged by the exposure to sugars. Glycation is a major source of tissue dysfunction in the elderly and is one of the major consequences of sustained hyperglycemia. AGE formation occurs in everyone and the process can lead to harmful inflammatory and autoimmune conditions. Glycated proteins have been found in the collagen of connective tissue, in arterial collagen, in kidney glomerular basement membrane, in the lens of the eye, in nerve myelin proteins and in the low-density lipoprotein circulating in the blood. The list of pathologies where glycation plays a role is extensive and includes vascular disease, erectile dysfunction, kidney disease, joint stiffness, loss of skin elasticity, arthritis, cataracts, retinopathy, neuropathy, Alzheimer's Dementia, impaired wound healing, urinary incontinence, complications of diabetes, and cardiomyopathies.
How does A.G.E. Amadori™ work?
A.G.E. Amadori™ has been formulated to prevent the glycation of proteins. The basis behind A.G.E. Amadori™ lies on two exceptional B vitamins: the world’s first pharmaceutical-grade Pyridox-amine, a form of vitamin B6, and Benfotiamine, a particularly bioavailable form of vitamin B1. Both nutrients are Amadorins because they prevent the formation of AGEs. Pyridox-amine inhibits AGE formation by hindering the degradation of Amadori intermediates, by scavenging toxic glucose byproducts and by trapping reactive oxygen species. Supplementation with high doses of benfotiamine can prevent metabolic damage associated with glycation by diverting excess metabolites toward the pentose pathway. Furthermore, benfotiamine can inhibit the three biochemical pathways involved in the pathogenesis of hyperglycemia. A.G.E. Amadori™ contains a wide spectrum of B vitamins, choline and inositol.
Research
The non-enzymatic glycation of proteins was first discovered with Hemoglobin A1c. This molecule is still used for the long-term management of diabetics. The formation of glycated proteins is a significant source of damage to the proteome and genome and is thought to play a central part in the development of diabetic complications and atherosclerosis. Hyperglycemic conditions such as diabetes accelerate the formation of modified proteins because increased levels of glucose in the blood accelerate the formation of AGE’s.
Pyridox-amine is an Amadorin; a post-Amadori AGE inhibitor. It prevents the conversion of protein Amadori intermediates to protein AGE’s. The vitamin can inhibit post Amodori steps of the Maillard reaction (the non-enzymatic reaction of sugars with amino acids) by sequestering catalytic metal ions and preventing the oxidative degradation of Amadori intermediates. Pyridox-amine prevents the formation of diabetic complications in animal models. In vitro, the molecule prevented the degradation of protein glycation intermediates, which would inhibit the chemical modification of tissue proteins.
Benfotiamine is a lipid soluble derivative of thiamine, with much better bioavailability, and it also interferes with the formation of AGE. In vitro experiments on human cells showed that the presence of benfotiamine in a high glucose environment reduced AGE formation to levels similar to the ones expected at normal blood glucose levels. It also allows normal cellular growth, a process normally impeded by the presence of high amounts of glucose. Benfotiamine’s value is related to its ability at inhibiting the three major pathways implicated in the pathogenesis of hyperglycemia. Benfotiamine stimulates transketolase activity and diverts excess metabolites towards the pentose pathway. In animals, the vitamin prevented diabetic retinopathy. An important finding for the treatment and prevention of complications associated with diabetes.
The health benefits associated with AGE inhibitors are significant. A.G.E. Amadori™ prevents the formation of glycated proteins. The synergistic combination of ingredients found in A.G.E. Amadori™ makes it a promising candidate for the treatment of diabetes and other conditions where oxidative reactions and carbonyl compounds convey pathogenicity. If you suffer from hyperglycemia, this supplement is a must; it is the most advanced supplement available for the prevention of glucose-mediated damage. If you do not suffer from elevated glucose levels, A.G.E. Amadori™ will lend you a hand for years to come, adverting tissue damage caused by AGE formation and accumulation.
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